Неврология
B1
Зависит от условий.
Суть
Тиамин (B1): витамин нервной ткани: при периферической нейропатии, включая алкогольную, лечение B1 улучшает симптомы; у здоровых без дефицита данных нет.
Что говорят исследования
Форма важна
Бенфотиамин или тиамин в B-комплексе.
Доза: по подтверждённому дефициту.
При алкоголизме профилактика от недостатка, а не «на всякий случай»..
Мифы
«B1 прокачивает здоровый мозг»: в МА 2021 эффект лишь у пациентов с нейропатией (n=3).
«Алкоголику витаминов хватает»: нейропатия при алкоголизме у 46%.
«Чем больше, тем лучше»: статус проверяют, не мегадозы.
Осторожно
В обычных дозах тиамин безопасен; ESPEN указывает на важность корректной оценки статуса; при алкогольной нейропатии ключевое: отказ от алкоголя.
С лекарствами
Из еды
Цельнозерновые крупы, бобовые, свинина, орехи, дрожжи; при алкоголизме и термообработке усвоение падает.
Источники
Association between neuropathy and B-vitamins: A systematic review and meta-analysis. 2021
Alcohol-related peripheral neuropathy: a systematic review and meta-analysis. 2019
ESPEN micronutrient guideline. 2022
Обзоры исследований: 39 в Europe PMC, самые цитируемые
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis. 2022 · цитирований: 82
The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review. 2018 · цитирований: 67
Thiamine supplementation for the treatment of heart failure: a review of the literature. 2013 · цитирований: 61
Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol. 2013 · цитирований: 61
Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. 2022 · цитирований: 56
Determining the Role of Thiamine Deficiency in Systolic Heart Failure: A Meta-Analysis and Systematic Review. 2015 · цитирований: 51
Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse. 2004 · цитирований: 48
Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. 2021 · цитирований: 40
Role of dietary protein and thiamine intakes on cognitive function in healthy older people: a systematic review. 2015 · цитирований: 33
Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. 2022 · цитирований: 23
Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis. 2020 · цитирований: 23
Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis. 2021 · цитирований: 22
Association between diabetes and thiamine status - A systematic review and meta-analysis. 2023 · цитирований: 21
Effect of vitamin B1 supplementation on blood creatinine and lactate levels and clinical outcomes in patients in intensive care units: a systematic review and meta-analysis of randomized controlled trials. 2024 · цитирований: 19
Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis. 2021 · цитирований: 19
Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. 2021 · цитирований: 18
Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis. 2021 · цитирований: 17
Does thiamine supplementation affect heart failure? A systematic review and meta-analysis of randomized control trials. 2023 · цитирований: 14
Thiamine for Alzheimer's disease. 2000 · цитирований: 13
A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction. 2025 · цитирований: 11
Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. 2022 · цитирований: 10
Thiamine for Alzheimer's disease. 2001 · цитирований: 10
Pre- and Post-surgical Prevalence of Thiamine Deficiency in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. 2024 · цитирований: 9
Vitamin B1 Intake and the Risk of Colorectal Cancer: a Systematic Review of Observational Studies. 2021 · цитирований: 9
Efficacy of Ascorbic Acid, Thiamine, and Hydrocortisone Combination Therapy: Meta-analysis of Randomized Controlled Trials. 2023 · цитирований: 8
The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials. 2022 · цитирований: 8
Intravenous thiamine for septic shock: A meta-analysis of randomized controlled trials. 2020 · цитирований: 8
Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials. 2024 · цитирований: 6
Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. 2023 · цитирований: 6
The Dichotomous Effect of Thiamine Supplementation on Tumorigenesis: A Systematic Review. 2022 · цитирований: 5
Оценка: Brain 25 Evidence (MIT).