Женское здоровье
Инозитол
Зависит от условий. Есть данные: гестационный диабет: RR 0.42. При условиях: СПКЯ умеренно.
Суть
Медиатор сигнала инсулина: гестационный диабет реже (RR 0.42); СПКЯ: живые роды не доказаны.
Что говорят исследования
Форма важна
Мио-инозитол 2–4 г/сут: дозы исследований.
При СПКЯ и ГДМ только с врачом, осторожно с литием..
Мифы
«Гарантирует беременность»: Cochrane: на живые роды эффекта не показано (OR пересекает 1).
«Вместо метформина»: нет, адъювант.
Осторожно
При СПКЯ: может снижать выкидыши, НО данные VERY LOW quality.
На живые роды эффекта не показано (OR 2.42, CI пересекает 1).
При гестационном диабете: профилактический эффект возможен, но данных мало.
НЕ замена метформину.
С лекарствами
Из еды
Зерновые, кукуруза, бобовые, мясо содержат мио-инозитол; дозы 2–4 г из еды недостижимы.
Источники
Inositol for subfertile women with polycystic ovary syndrome. 2018 Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. 2023 Meta-Analysis, Journal Article, Review, Research Support, Non-U.S. Gov't
Efficacy of inositol supplementation for the prevention and treatment of gestational diabetes in pregnant women: Results from an umbrella meta-analysis. 2026 Journal Article, Meta-Analysis, Systematic Review
Обзоры исследований: 65 в Europe PMC, самые цитируемые
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. 2017 · цитирований: 158
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. 2012 · цитирований: 134
Effects of myo-inositol in women with PCOS: a systematic review of randomized controlled trials. 2012 · цитирований: 107
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. 2023 · цитирований: 73
Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. 2003 · цитирований: 72
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. 2018 · цитирований: 71
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis. 2021 · цитирований: 67
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. 2010 · цитирований: 66
A meta-analysis of inositol for depression and anxiety disorders. 2014 · цитирований: 58
Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials. 2019 · цитирований: 55
Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. 2018 · цитирований: 53
Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. 2015 · цитирований: 51
Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials. 2019 · цитирований: 46
Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of <sup>1</sup>H-MRS Studies of Medial Prefrontal Myo-Inositol. 2018 · цитирований: 43
Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET. 2017 · цитирований: 42
Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. 2020 · цитирований: 34
Relationship Between Myo-Inositol Supplementary and Gestational Diabetes Mellitus: A Meta-Analysis. 2015 · цитирований: 33
Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines. 2024 · цитирований: 32
The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. 2018 · цитирований: 31
Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes. 2016 · цитирований: 31
Preventive and Therapeutic Role of Dietary Inositol Supplementation in Periconceptional Period and During Pregnancy: A Summary of Evidences and Future Applications. 2016 · цитирований: 30
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. 2009 · цитирований: 30
Inositol in preterm infants at risk for or having respiratory distress syndrome. 2019 · цитирований: 27
Inositol for subfertile women with polycystic ovary syndrome. 2018 · цитирований: 27
The efficacy of myo-inositol supplementation to prevent gestational diabetes onset: a meta-analysis of randomized controlled trials. 2019 · цитирований: 27
Myo-inositol lowers the risk of developing gestational diabetic mellitus in pregnancies: A systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. 2018 · цитирований: 25
D-Chiro-inositol and its significance in polycystic ovary syndrome: a systematic review. 2011 · цитирований: 25
Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. 2023 · цитирований: 23
Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2022 · цитирований: 22
Оценка: Brain 25 Evidence (MIT).