Воспаление
Куркумин
Зависит от условий. При условиях: настроение адъюнктивно при депрессии, масса тела, ИМТ и окружность талии ниже.
Суть
Полифенол куркумы: воспаление (NF-κB); биодоступность сама по себе плохая.
Что говорят исследования
Форма важна
Стандартизация 95% куркуминоидов + пиперин либо фосфосомные/жидкие формы.
«порошок куркумы в капсуле» слаб..
Мифы
«Куркума в еде = доза добавки»: в 1-2 г порошка 30-60 мг куркумина с плохим всасыванием.
«Полностью лечит воспаление»: эффект скромный.
Осторожно
Биодоступность куркумина ОЧЕНЬ низкая без усилителей (пиперин, липосомы, наночастицы).
Cochrane: работает для поддержания ремиссии при язвенном колите.
Для ОА: умеренный эффект.
Для похудения/рака: данные слабые.
Осторожно: желчнокаменная болезнь, антикоагулянты.
С лекарствами
Из еды
Куркума в пище (около 3% куркумина); с пиперином и жирами всасывание выше.
Источники
The Effects of Curcumin Supplementation on Body Weight, Body Mass Index, and Waist Circumference in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2026 Journal Article, Systematic Review, Meta-Analysis
Curcumin Supplementation in Critically Ill Patients: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trial. 2026 Journal Article, Meta-Analysis, Systematic Review
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-analysis. 2022 Journal Article, Meta-Analysis, Systematic Review
Обзоры исследований: 311 в Europe PMC, самые цитируемые
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). 2003 · цитирований: 633
Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. 2018 · цитирований: 305
Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials. 2016 · цитирований: 236
Clinical effects of curcumin in enhancing cancer therapy: A systematic review. 2020 · цитирований: 232
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. 2006 · цитирований: 225
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. 2016 · цитирований: 209
Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. 2017 · цитирований: 146
The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies. 2019 · цитирований: 142
Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence. 2016 · цитирований: 132
Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. 2016 · цитирований: 129
The Effects of Curcumin on Diabetes Mellitus: A Systematic Review. 2021 · цитирований: 127
Curcumin for depression: a meta-analysis. 2020 · цитирований: 125
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases. 2016 · цитирований: 125
A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health. 2020 · цитирований: 123
Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. 2023 · цитирований: 114
Clinical Use of Curcumin in Depression: A Meta-Analysis. 2017 · цитирований: 114
Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review. 2020 · цитирований: 113
Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review. 2022 · цитирований: 105
Efficacy and Safety of Curcumin and <i>Curcuma longa</i> Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. 2022 · цитирований: 102
The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. 2019 · цитирований: 98
A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. 2014 · цитирований: 98
Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials. 2022 · цитирований: 85
Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials. 2019 · цитирований: 81
Trends in advanced oral drug delivery system for curcumin: A systematic review. 2022 · цитирований: 69
The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. 2021 · цитирований: 68
The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials. 2016 · цитирований: 68
The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2019 · цитирований: 67
Curcumin supplementation improves biomarkers of oxidative stress and inflammation in conditions of obesity, type 2 diabetes and NAFLD: updating the status of clinical evidence. 2021 · цитирований: 66
Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials. 2021 · цитирований: 66
Оценка: Brain 25 Evidence (MIT).