Иммунитет
Лактоферрин
Работает. При условиях: железо: контекст.
Суть
Гликопротеин молока: недоношенным ниже поздний сепсис (2 Cochrane); детям: сепсис и диарея, не ОРВИ.
Что говорят исследования
Форма важна
100-200 мг/сут лактоферрина.
Для недоношенных: только по назначению.
Осторожно при аллергии на молоко..
Мифы
«Убивает все инфекции»: от ОРВИ у детей без эффекта (OR 0.61, NS).
«Работает у взрослых»: доказательства неонатальные/детские.
Осторожно
Лактоферрин: гликопротеин молока.
Для недоношенных: 2 Cochrane-обзора подтверждают профилактику позднего сепсиса и НЭК.
Для педиатрических инфекций: есть данные.
Для статуса железа: улучшает абсорбцию.
Безопасен.
Осторожно: аллергия на молочный белок.
С лекарствами
Из еды
Лактоферрин: в грудном молоке (особенно молозиве) и коровьем; добавка: извлечённый белок.
Источники
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. 2020 Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. 2017 Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Systematic Review
Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis. 2025 Journal Article, Systematic Review, Meta-Analysis
Обзоры исследований: 42 в Europe PMC, самые цитируемые
C-Reactive Protein, Fecal Calprotectin, and Stool Lactoferrin for Detection of Endoscopic Activity in Symptomatic Inflammatory Bowel Disease Patients: A Systematic Review and Meta-Analysis. 2015 · цитирований: 555
A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. 2015 · цитирований: 254
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. 2017 · цитирований: 101
Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. 2020 · цитирований: 90
Longitudinal changes in lactoferrin concentrations in human milk: a global systematic review. 2014 · цитирований: 89
Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants: A Systematic Review and Network Meta-Analysis. 2023 · цитирований: 68
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 2015 · цитирований: 63
Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis. 2018 · цитирований: 48
Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis. 2022 · цитирований: 44
Salivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions. 2020 · цитирований: 44
Factors affecting lactoferrin concentration in human milk: how much do we know? 2017 · цитирований: 44
Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials. 2022 · цитирований: 38
Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis. 2020 · цитирований: 37
The immunomodulatory effects of lactoferrin and its derived peptides on NF-κB signaling pathway: A systematic review and meta-analysis. 2023 · цитирований: 35
Fecal lactoferrin in discriminating inflammatory bowel disease from irritable bowel syndrome: a diagnostic meta-analysis. 2014 · цитирований: 34
Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials. 2021 · цитирований: 33
Fecal Lactoferrin for Assessment of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis. 2020 · цитирований: 31
Diagnostic accuracy of fecal lactoferrin for inflammatory bowel disease: a meta-analysis. 2015 · цитирований: 30
The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review. 2022 · цитирований: 28
Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. 2017 · цитирований: 27
Meta-analysis: efficacy of bovine lactoferrin in Helicobacter pylori eradication. 2009 · цитирований: 27
A systematic review of lactoferrin use in dermatology. 2017 · цитирований: 25
Impact of lactoferrin on bone regenerative processes and its possible implementation in oral surgery - a systematic review of novel studies with metanalysis and metaregression. 2020 · цитирований: 21
Role of lactoferrin in neonatal care: a systematic review. 2017 · цитирований: 21
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 2011 · цитирований: 19
Oral fate and stabilization technologies of lactoferrin: a systematic review. 2022 · цитирований: 18
Lactoferrin Supplementation to Prevent Late-Onset Sepsis in Preterm Infants: A Meta-Analysis. 2021 · цитирований: 17
Meta-analysis: the effect of supplementation with lactoferrin on eradication rates and adverse events during Helicobacter pylori eradication therapy. 2009 · цитирований: 17
Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials. 2019 · цитирований: 12
Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants. 2010 · цитирований: 11
Оценка: Brain 25 Evidence (MIT).