Психика
SAMe
Работает. При условиях: депрессия адъюнкт: малые МА, печёночные показатели лучше, НЯ редкие.
Суть
Донор метильных групп; помогает при депрессии (адъювант), боли при остеоартрозе и поддержке печени.
Что говорят исследования
Форма важна
Кишечнорастворимые формы, 400–800 мг/д натощак.
При депрессии/биполярке: только с врачом. Дорого..
Мифы
«Мгновенно поднимает настроение»: при большой депрессии эффект отсрочен.
«Безобиден при биполярке»: риск мании, только с врачом.
Осторожно
SAMe (S-аденозилметионин): универсальный донор метильных групп.
Для депрессии: эффективность сравнима с СИОЗС в РКИ.
Для остеоартрита: Cochrane-обзор PubMed подтверждает обезболивающий эффект.
Для печени: есть данные.
Для биполярного расстройства: ОСТОРОЖНО (риск мании).
Высокая цена, низкая стабильность: нужны кишечнорастворимые формы.
Доза: 400-1600 мг/день.
С лекарствами
Из еды
Из еды напрямую не набрать: синтезируется организмом из метионина (яйца, рыба, бобовые).
Источники
S-Adenosylmethionine for osteoarthritis of the knee or hip. 2009 Journal Article, Meta-Analysis, Systematic Review
S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. 2005 Journal Article, Research Support, U.S. Gov't, P.H.S., Systematic Review
S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review. 2024 Journal Article, Systematic Review
Обзоры исследований: 226 в Europe PMC, самые цитируемые
What are the most effective intervention techniques for changing physical activity self-efficacy and physical activity behaviour--and are they the same? 2011 · цитирований: 397
Cochrane reviews compared with industry supported meta-analyses and other meta-analyses of the same drugs: systematic review. 2006 · цитирований: 271
The Shift to Same-Day Outpatient Joint Arthroplasty: A Systematic Review. 2018 · цитирований: 184
A meta-analytic review of achievement goal measures: different labels for the same constructs or different constructs with similar labels? 2010 · цитирований: 158
S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. 2017 · цитирований: 111
Words do matter: a systematic review on how different terminology for the same condition influences management preferences. 2017 · цитирований: 110
Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review. 2020 · цитирований: 106
Safety and tolerability of long-acting injectable versus oral antipsychotics: A meta-analysis of randomized controlled studies comparing the same antipsychotics. 2016 · цитирований: 105
Is there a trial bias impacting user engagement with unguided e-mental health interventions? A systematic comparison of published reports and real-world usage of the same programs. 2019 · цитирований: 103
Same-level peer-assisted learning in medical clinical placements: a narrative systematic review. 2016 · цитирований: 90
Prospective, randomized, open-label, blinded-endpoint (PROBE) designed trials yield the same results as double-blind, placebo-controlled trials with respect to ABPM measurements. 2003 · цитирований: 90
Disclosure of Same-Sex Behaviors to Health-care Providers and Uptake of HIV Testing for Men Who Have Sex With Men: A Systematic Review. 2018 · цитирований: 89
Epidemiology of male same-sex behaviour and associated sexual health indicators in low- and middle-income countries: 2003-2007 estimates. 2008 · цитирований: 89
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. 1994 · цитирований: 87
Diagnostic accuracy of same-day microscopy versus standard microscopy for pulmonary tuberculosis: a systematic review and meta-analysis. 2013 · цитирований: 86
Same-day discharge compared with overnight hospitalization after uncomplicated percutaneous coronary intervention: a systematic review and meta-analysis. 2013 · цитирований: 80
Systematic review of same-day discharge after minimally invasive hysterectomy. 2017 · цитирований: 78
Sexual addiction or hypersexual disorder: different terms for the same problem? A review of the literature. 2014 · цитирований: 78
Same-day discharge after percutaneous coronary intervention: a meta-analysis. 2013 · цитирований: 78
Venous thromboembolism has the same risk factors as atherosclerosis: A PRISMA-compliant systemic review and meta-analysis. 2016 · цитирований: 77
Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis? 2012 · цитирований: 77
Addition of long-acting beta2-agonists to inhaled corticosteroids versus same dose inhaled corticosteroids for chronic asthma in adults and children. 2010 · цитирований: 77
Impact of Single Combination Inhaler versus Multiple Inhalers to Deliver the Same Medications for Patients with Asthma or COPD: A Systematic Literature Review. 2020 · цитирований: 65
Systematic Differences between Cochrane and Non-Cochrane Meta-Analyses on the Same Topic: A Matched Pair Analysis. 2015 · цитирований: 59
S-adenosyl methionine (SAMe) for depression in adults. 2016 · цитирований: 57
Do elderly systolic heart failure patients benefit from beta blockers to the same extent as the non-elderly? Meta-analysis of >12,000 patients in large-scale clinical trials. 2005 · цитирований: 56
The effects of same-session combined exercise training on cardiorespiratory and functional fitness in older adults: a systematic review and meta-analysis. 2019 · цитирований: 55
Does Aerobic Training Promote the Same Skeletal Muscle Hypertrophy as Resistance Training? A Systematic Review and Meta-Analysis. 2019 · цитирований: 55
Same or Different: The Overlap Between Children With Auditory Processing Disorders and Children With Other Developmental Disorders: A Systematic Review. 2018 · цитирований: 55
Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review. 2021 · цитирований: 53
Оценка: Brain 25 Evidence (MIT).