Когниция
Тирозин
Не доказано. При условиях: когниция ТОЛЬКО при остром стрессе/недосыпе.
Суть
Предшественник дофамина: удерживает рабочую память при остром стрессе/недосыпе; на спорт не влияет.
Что говорят исследования
Форма важна
Л-тирозин 500–2000 мг однократно под стресс (соревнование, ночь без сна).
Не для постоянного приёма..
Мифы
«Разгоняет мозг всем»: только на фоне истощённых катехоламинов.
«Спортивный допинг»: результативность не растёт.
Осторожно
ВСЕГО 1 релевантный мета-анализ после скрининга (остальные: про ингибиторы тирозинкиназы в онкологии, не про аминокислоту).
Для когнитивных функций при стрессе: данные единичных РКИ, низкое качество.
Для спортивных результатов: нет систематических пруфов.
С лекарствами
Из еды
Сыр, курица, рыба, индейка, арахис, бананы; для острой нагрузки проще Л-тирозин 500–2000 мг.
Источники
Behavioral and cognitive effects of tyrosine intake in healthy human adults. 2015 Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
Обзоры исследований: 416 в Europe PMC, самые цитируемые
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. 2012 · цитирований: 461
Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. 2009 · цитирований: 218
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. 2005 · цитирований: 200
Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis. 2012 · цитирований: 181
Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for the differential diagnosis of primary brain tumor: a systematic review and Metaanalysis. 2012 · цитирований: 148
Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors. 2012 · цитирований: 137
Meta-Analysis and Systematic Review to Assess the Role of Soluble FMS-Like Tyrosine Kinase-1 and Placenta Growth Factor Ratio in Prediction of Preeclampsia: The SaPPPhirE Study. 2018 · цитирований: 131
Risk of Treatment-Related Toxicities from EGFR Tyrosine Kinase Inhibitors: A Meta-analysis of Clinical Trials of Gefitinib, Erlotinib, and Afatinib in Advanced EGFR-Mutated Non-Small Cell Lung Cancer. 2017 · цитирований: 125
Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis. 2014 · цитирований: 120
Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures. 2021 · цитирований: 116
Skin rash could predict the response to EGFR tyrosine kinase inhibitor and the prognosis for patients with non-small cell lung cancer: a systematic review and meta-analysis. 2013 · цитирований: 115
Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-EGFR tyrosine kinase inhibitors: a literature-based meta-analysis of 24 trials. 2012 · цитирований: 114
Systematic review of infectious events with the Bruton tyrosine kinase inhibitor ibrutinib in the treatment of hematologic malignancies. 2018 · цитирований: 107
Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. 2010 · цитирований: 106
QTc interval prolongation with vascular endothelial growth factor receptor tyrosine kinase inhibitors. 2015 · цитирований: 97
Tyrosine, phenylalanine, and tryptophan in gastroesophageal malignancy: a systematic review. 2015 · цитирований: 95
EGFR tyrosine kinase inhibitors versus cranial radiation therapy for EGFR mutant non-small cell lung cancer with brain metastases: a systematic review and meta-analysis. 2015 · цитирований: 89
Congestive heart failure with vascular endothelial growth factor receptor tyrosine kinase inhibitors. 2015 · цитирований: 89
Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis. 2015 · цитирований: 84
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. 2012 · цитирований: 80
Outcome of patients with lung adenocarcinoma with transformation to small-cell lung cancer following tyrosine kinase inhibitors treatment: A systematic review and pooled analysis. 2017 · цитирований: 74
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review. 2010 · цитирований: 73
Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: a meta-analysis. 2013 · цитирований: 72
Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: a meta-analysis. 2011 · цитирований: 72
Оценка: Brain 25 Evidence (MIT).